There may be some situations when the user is unable to open a design within the BERNINA UI (User Interface) for E 16. The UI will open, it connects with the machine, but many of the UI features are grayed out (can't access thread or hoops for example). If the user tries to open a design, the message appears that "loading design to machine failed. Invalid design file or file too large to load."
The solution is to first open the design in the BERNINA OS, then select Tools > Restart in UI. The design should then load. This process appears to clear the blockage.